RIFAMPICIN

ORANGE DISCOLOURATION

Q. Which of the following side effects occurs commonly with the administration of rifampin for N. meningitides chemoprophylaxis?
A. Liver failure
B. Renal failure
C. Orange discoloration of secretions
D. Anemia
E. Leukopenia

Ans: C.

Rifampin will turn all of an individual’s secretions, such as urine, sweat, tears, and stool, an orange color. Contact lenses can be permanently stained with this orange discoloration. This side

effect is a source of great consternation to individuals who are not warned of its possibility.